Lectin functionalized nanocarriers for gene delivery. –

PubMed ID: 23347981

Author(s): Gajbhiye V, Gong S. Lectin functionalized nanocarriers for gene delivery. Biotechnol Adv. 2013 Sep-Oct;31(5):552-62. doi: 10.1016/j.biotechadv.2013.01.005. Epub 2013 Jan 21. Review. PMID 23347981

Journal: Biotechnology Advances, Volume 31, Issue 5, 2013

Gene therapy has emerged as one of the most promising therapeutic methods to treat various diseases. However, inadequate gene transfection efficacy during gene therapy demands further development of more efficient gene delivery strategies. Targeting genetic material to specific sites of action endows numerous advantages over non-targeted delivery. An ample variety of non-viral gene delivery vectors have been developed in recent years owing to the safety issues raised by viral vectors. Non-viral gene delivery vectors containing specific targeting ligands on their surfaces have been reported to enhance the gene transfection efficiency via receptor-mediated endocytosis for gene delivery. Among various targeting moieties investigated, carbohydrates and lectins (carbohydrate-binding proteins) played an essential role in gene delivery via either direct or reverse lectin targeting strategies. Lectins have a specific carbohydrate binding domain that can bind specifically to the carbohydrates. This review sheds light on various gene delivery nanovectors conjugated with either lectins or carbohydrates for enhanced gene transfection.