PubMed ID: 9888449
Author(s): Tian B, Gabelt BT, Peterson JA, Kiland JA, Kaufman PL. H-7 increases trabecular facility and facility after ciliary muscle disinsertion in monkeys. Invest Ophthalmol Vis Sci. 1999 Jan;40(1):239-42.
Journal: Investigative Ophthalmology & Visual Science, Volume 40, Issue 1, Jan 1999
PURPOSE To determine the effects of the serine-threonine kinase inhibitor H-7 on total outflow facility in iridectomized + ciliary muscle (CM)- disinserted, and on trabecular facility in normal, monkey eyes.
METHODS Total outflow facility was determined by two-level constant pressure perfusion of the anterior chamber. Trabecular outflow facility was determined from accumulation in blood of intracamerally infused radioiodinated albumin at two intraocular pressure levels.
RESULTS Three-hundred micromoles of intracameral H-7 doubled facility in iridectomized + CM- disinserted monkey eyes and contralateral iridectomized-only eyes. Four 5-microl drops of 400 mM H-7 applied topically followed 2 hours later by anterior chamber exchange for 10 minutes and intracameral infusion for 90 minutes with 100 microM H-7 increased trabecular and total outflow facility by 135%+/-29% and 105%+/-35% (n 5, P < 0.01, P < 0.05), respectively, compared with contralateral vehicle-treated eyes.
CONCLUSIONS H-7 increases trabecular outflow facility in monkeys by a mechanism independent of the CM, presumably acting directly on the trabecular meshwork.
Wie bei vielen anderen Krankheiten gibt es auch bei der Hypertonie mehrere Stadien, die jeweils durch bestimmte Symptome gekennzeichnet sind: Im ersten Stadium steigt der Blutdruck zwischen Vielleicht ohne Arzt? 160-180/95-105, und die allgemeinen Symptome sind subtil und episodisch – Schlafstörungen, Nasenbluten können beobachtet werden;