Retinal cells grown from stem cells can reach out and connect with neighbors, according to a new study, completing a “handshake” that may show the cells are ready for trials in humans with degenerative eye disorders.
PubMed ID: 11231777 Author(s): Gamm DM, Thliveris AT. Implications of genetic analysis in Leber congenital amaurosis. Arch Ophthalmol. 2001 Mar;119(3):426-7. PMID 11231777 Journal: Archives Of Ophthalmology (Chicago, Ill. : 1960), Volume 119, Issue 3, Mar 2001
PubMed ID: 10937596 Author(s): Gamm DM, Barthel LK, Raymond PA, Uhler MD. Localization of cGMP-dependent protein kinase isoforms in mouse eye. Invest Ophthalmol Vis Sci. 2000 Aug;41(9):2766-73. PMID 10937596 Journal: Investigative Ophthalmology & Visual Science, Volume 41, Issue 9, Aug 2000 PURPOSE To examine the expression of the major isoforms of cyclic guanosine monophosphate (cGMP)-dependent …
PubMed ID: 10642527 Author(s): Collins SP, Reoma JL, Gamm DM, Uhler MD. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem J. 2000 Feb 1;345 Pt 3:673-80. PMID 10642527 Journal: The Biochemical Journal, Volume 345 Pt 3, Issue Pt 3, Feb 2000 …
PubMed ID: 9920894 Author(s): Hall KU, Collins SP, Gamm DM, Massa E, DePaoli-Roach AA, Uhler MD. Phosphorylation-dependent inhibition of protein phosphatase-1 by G-substrate. A Purkinje cell substrate of the cyclic GMP-dependent protein kinase. J Biol Chem. 1999 Feb 5;274(6):3485-95. Journal: The Journal Of Biological Chemistry, Volume 274, Issue 6, Feb 1999 G-substrate, a specific substrate …
PubMed ID: 8662989 Author(s): Gamm DM, Baude EJ, Uhler MD. The major catalytic subunit isoforms of cAMP-dependent protein kinase have distinct biochemical properties in vitro and in vivo. J Biol Chem. 1996 Jun 28;271(26):15736-42. Journal: The Journal Of Biological Chemistry, Volume 271, Issue 26, Jun 1996 Two isoforms of the catalytic subunit of cAMP-dependent protein …
PubMed ID: 7593002 Author(s): Gamm DM, Francis SH, Angelotti TP, Corbin JD, Uhler MD. The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J Biol Chem. 1995 Nov 10;270(45):27380-8. Journal: The Journal Of Biological Chemistry, Volume 270, Issue 45, Nov 1995 The …
PubMed ID: 7706262 Author(s): Gamm DM, Uhler MD. Isoform-specific differences in the potencies of murine protein kinase inhibitors are due to nonconserved amino-terminal residues. J Biol Chem. 1995 Mar 31;270(13):7227-32. Journal: The Journal Of Biological Chemistry, Volume 270, Issue 13, Mar 1995 We provide here a detailed characterization of two isoforms of the protein kinase …
PubMed ID: 7878050 Author(s): Seasholtz AF, Gamm DM, Ballestero RP, Scarpetta MA, Uhler MD. Differential expression of mRNAs for protein kinase inhibitor isoforms in mouse brain. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1734-8. Journal: Proceedings Of The National Academy Of Sciences Of The United States Of America, Volume 92, Issue 5, Feb …