Repeatability of retinal thickness measurements between spectral-domain and time-domain optical coherence tomography images in macular disease. –

PubMed ID: 20415296

Author(s): Domalpally A, Gangaputra S, Peng Q, Danis RP. Repeatability of retinal thickness measurements between spectral-domain and time-domain optical coherence tomography images in macular disease. Ophthalmic Surg Lasers Imaging. 2010 Nov-Dec;41 Suppl:S34-41. doi: 10.3928/15428877-20100325-01. Epub 2010 Mar 30. PMID 20415296

Journal: Ophthalmic Surgery, Lasers & Imaging : The Official Journal Of The International Society For Imaging In The Eye, Volume 41 Suppl, 2010

BACKGROUND AND OBJECTIVE To evaluate and compare the intra-session repeatability of retinal thickness measurements from the Topcon 3D OCT 1000 (Topcon Medical Systems; Paramus, NJ), a spectral-domain optical coherence tomography (SD-OCT) system, with the Stratus (Carl Zeiss Meditec, Inc., Dublin, CA), a time-domain OCT (TD-OCT) system, in eyes with retinal diseases.

PATIENTS AND METHODS Repeated scans with both SD-OCT and TD-OCT were taken. Thickness measurements from high-quality scans were used to assess repeatability and compare measurements between the two instruments.

RESULTS Paired scans from 127 eyes were evaluated, of which 63 pairs were of high quality. Coefficients of repeatability and variation for the central subfield were 20.1 μm (2.6%) with SD-OCT and 27.4 μm (4%) with TD-OCT (P = .38). The mean difference in central subfield thickness between the two instruments was 24.5 μm (standard deviation = 20.9).

CONCLUSION Repeatability of retinal thickness measurements with the Topcon 3D OCT 1000 is comparable to the Stratus. The measurements of the two machines differ significantly and cannot be used interchangeably.